A New Era of Disease Modification
Harnessing Serotonin Biology to Reverse Eye and Brain Degeneration
Precision Serotonergic Therapies for Regeneration and Protection
2A Biosciences pioneers life-changing therapies for the 400M+ people globally suffering from degenerative eye and brain diseases. Our proprietary small molecules activate serotonin 2A receptors to unlock regenerative, anti-inflammatory, and neuroprotective outcomes through precise molecular designs.
Targeting Root Causes of Neuro-degeneration
Serotonin 2A receptors - long misunderstood as purely psychotropic - are now known to be powerful modulators of inflammation and regeneration.
Our serotonergics are the first to systematically harness this biology to treat neurodegeneration, addressing root disease causes like mitochondrial dysfunction, oxidative stress, and inflammation, while simultaneously promoting neuronal growth and plasticity.
Our lead program is on track to enter Phase 2a trials.
Backed by Established Science
Serotonin, Immune Function, and Psychedelics as Potent Anti-Inflammatories
Charles D. Nichols, Timothy P. Foster
From Psychiatry to Neurology: Psychedelics as Prospective Therapeutics for Neurodegenerative Disorders
Urszula Kozlowska, Charles D. Nichols, Kalina Wiatr, Maciej Figiel
Psychedelics and Anti-Inflammatory Activity in Animal Models
Thomas W. Flanagan, Charles D. Nichols
5-HT2A receptors: Pharmacology and Functional Selectivity
Benjamin R. Cummins, Gerald B. Billac, David E. Nichols, Charles D. Nichols
History of Psychedelic Drug Science and Molecular Pharmacology
David E. Nichols, Charles D. Nichols
The Structural Diversity of Psychedelic Drug Actions Revealed
Ryan H Gumpper, Manish K Jain, Kuglae Kim, Renhong Sun, Ning Sun, Zhongli Xu, Jeffrey F DiBerto, Brian E Krumm, Nicholas J Kapolka, H Ümit Kaniskan, David E Nichols, Jian Jin, Jonathan F Fay, Bryan L Roth
